US 11,672,583 B2
Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor
Mark A. Grant, Winnipeg (CA); and Richard Tyc, Winnipeg (CA)
Assigned to MONTERIS MEDICAL CORPORATION, Minnetonka, MN (US)
Filed by Monteris Medical Corporation, Plymouth, MN (US)
Filed on Apr. 29, 2019, as Appl. No. 16/397,015.
Application 16/397,015 is a continuation of application No. 14/841,109, filed on Aug. 31, 2015, granted, now 10,327,830.
Claims priority of provisional application 62/141,612, filed on Apr. 1, 2015.
Prior Publication US 2019/0262057 A1, Aug. 29, 2019
Int. Cl. A61B 18/02 (2006.01); A61B 18/04 (2006.01); A61B 18/08 (2006.01); A61B 18/20 (2006.01); A61B 18/22 (2006.01); A61N 7/02 (2006.01); A61B 18/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 18/02 (2013.01) [A61B 18/04 (2013.01); A61B 18/082 (2013.01); A61B 18/22 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00738 (2013.01); A61B 2018/0231 (2013.01); A61B 2018/0262 (2013.01); A61B 2018/046 (2013.01); A61B 2018/20361 (2017.05); A61B 2018/2266 (2013.01); A61B 2090/036 (2016.02); A61B 2090/3937 (2016.02); A61N 7/022 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A system for performing temperature modulation therapy to a tissue with an interstitial probe, the system comprising:
an interstitial probe, comprising a shaft region, a tip region, at least one thermal therapy-generating element for thermal therapy emission via the tip region, and at least one cryotherapy-generating element for cryogenic therapy emission via the tip region;
processing circuitry; and
a memory having instructions stored thereon, wherein the instructions, when executed by the processing circuitry, cause the processing circuitry to, while the interstitial probe is positioned proximate a tissue:
determine a thermal dose for effecting thermal therapy treatment based on a present position of the interstitial probe,
identify, based at least in part upon the thermal dose, a modulation pattern comprising at least one cycle of lower thermal output interspersed between two higher thermal outputs, wherein a higher thermal output corresponds to activation of a first thermal therapy element of the at least one thermal therapy-generating element for a first time interval and the lower thermal output corresponds to activation of a first cryogenic therapy element of the at least one cryogenic therapy element for a second time interval,
activate, at the present position of the interstitial probe, temperature modulation therapy by the interstitial probe utilizing the identified modulation pattern for applying the thermal dose to the tissue,
during the application of the thermal dose via the modulation therapy, monitor at least one temperature of the tissue,
identify a difference between a goal temperature corresponding to the thermal dose and the at least one temperature of the tissue, and
responsive to identifying the difference, alter the modulation pattern, wherein altering the modulation pattern comprises altering at least one of a) a length of the first time interval, b) a length of the second time interval, c) an emission level of the first thermal therapy-generating element during the first time interval, d) an emission level of the first thermal therapy-generating element during the second time interval, e) an emission level of the first cryotherapy-generating element during the first time interval, and f) an emission level of the first cryotherapy-generating element during the second time interval.