CPC H01J 49/0081 (2013.01) [G01N 30/7233 (2013.01); G01N 30/8631 (2013.01); H01J 49/0036 (2013.01); G01N 2030/027 (2013.01)] | 31 Claims |
1. A method of performing tandem mass spectrometry comprising:
supplying a sample to a chromatography column;
directing components included in the sample and eluting from the chromatography column to a mass spectrometer;
acquiring a series of mass spectra including intensity values of ions produced from the components as a function of m/z of the ions;
extracting, from the series of mass spectra, a plurality of detection points representing intensity as a function of time for a selected m/z;
estimating, based on the plurality of detection points extracted from the series of mass spectra and using an algorithm trained to estimate a normalized intensity value of selected detection points, a relative position of a selected detection point included in the plurality of detection points, the relative position of the selected detection point representing a position of the selected detection point relative to an expected reference point; and
performing, at the mass spectrometer and based on the estimated relative position of the selected detection point relative to an expected reference point, a dependent acquisition for the selected m/z.
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