CPC G16H 20/17 (2018.01) [G16C 20/30 (2019.02); G16H 50/20 (2018.01); G16H 50/50 (2018.01); G16H 50/70 (2018.01); A61K 49/0004 (2013.01); A61P 7/04 (2018.01); G06N 7/01 (2023.01); G16C 20/50 (2019.02); G16C 20/70 (2019.02)] | 15 Claims |
1. A method for providing a clotting factor VIII dosing regimen comprising:
determining a clotting factor VIII clearance for a patient based on two blood samples collected from the patient after an infusion of clotting factor VIII;
determining if a patient has a half-life greater than a predetermined threshold;
determining, via a processor, an estimated pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients, the estimated pharmacokinetic profile based upon at least one of a body weight or an age of the patient such that:
a first weighting factor is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the half-life of the patient is greater than the predetermined threshold, and
a second weighting factor, less than the first weighting factor, is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the half-life of the patient is less than the predetermined threshold;
determining, via the processor, a dosing regimen for a specified dosing interval including (i) a dosage and (ii) an estimated clotting factor VIII clearance for the patient over a time period based at least upon the estimated pharmacokinetic profile;
displaying the dosing regimen on a client device; and
administering clotting factor VIII based on the dosing regimen.
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