US 11,668,844 B2
System and method for the detection of gamma radiation from a radioactive analyte
Joshua G. Knowland, Cary, NC (US); Charles W. Scarantino, Raleigh, NC (US); and Ronald K. Lattanze, Morrisville, NC (US)
Assigned to Lucerno Dynamics, LLC, Cary, NC (US)
Filed by Lucerno Dynamics, LLC, Cary, NC (US)
Filed on Oct. 29, 2020, as Appl. No. 17/83,875.
Application 15/885,112 is a division of application No. 14/678,550, filed on Apr. 3, 2015, granted, now 9,939,533, issued on Apr. 10, 2018.
Application 17/083,875 is a continuation of application No. 15/885,112, filed on Jan. 31, 2018, granted, now 10,852,446.
Application 14/678,550 is a continuation in part of application No. 13/840,925, filed on Mar. 15, 2013, granted, now 9,002,438, issued on Apr. 7, 2015.
Claims priority of provisional application 61/653,014, filed on May 30, 2012.
Prior Publication US 2021/0055431 A1, Feb. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01T 1/161 (2006.01); A61B 6/00 (2006.01); G01T 1/164 (2006.01)
CPC G01T 1/161 (2013.01) [A61B 6/4258 (2013.01); A61B 6/463 (2013.01); G01T 1/1612 (2013.01); G01T 1/1648 (2013.01); A61B 6/467 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for the ex vivo real-time detection over a period of time of gamma radiation emitted by a subject from the administration of a radioactive analyte that decays in vivo, the system comprising:
at least one ex vivo gamma radiation measurement sensor to detect gamma radiation over a desired period of time and to produce signal data associated with the desired period of time, the ex vivo measurement sensor adapted to sensing gamma radiation proximate to a point of administration on the subject of the radioactive analyte;
a signal amplifier in operable communication with the gamma radiation sensor, the signal amplifier adapted to amplify the signal data, the measurement sensor having at least one sensor output for such amplified signal data;
at least one computer processor and a non-transient memory, the computer processor in operable communication with the non-transient memory and the measurement sensor output port;
wherein the non-transient memory includes computer program code executable by the at least one computer processor, the computer program code configured for performing the steps of receiving the amplified signal data with the desired period of time and one or more associated patient administration factors, accessing reference data distributed over a reference period of time and one or more associated reference administration factors, and comparing the amplified signal data and patient administration factors to the reference data and reference administration factors to determine a likelihood of improper administration of the radioactive analyte to the subject and administration factors associated with improper administration.