US 11,668,707 B2
Simultaneous measurement of multiple analytes of a liquid assay
Jacques Brunelle, Franklin, MA (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Appl. No. 16/468,963
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
PCT Filed Dec. 12, 2017, PCT No. PCT/US2017/065737
§ 371(c)(1), (2) Date Jun. 12, 2019,
PCT Pub. No. WO2018/111829, PCT Pub. Date Jun. 21, 2018.
Claims priority of provisional application 62/435,353, filed on Dec. 16, 2016.
Prior Publication US 2020/0080994 A1, Mar. 12, 2020
Int. Cl. G01N 33/536 (2006.01); G01N 21/27 (2006.01); G01N 21/31 (2006.01); G01N 21/77 (2006.01); G01N 33/72 (2006.01); G01N 35/10 (2006.01); G01N 21/82 (2006.01); G01J 3/10 (2006.01); G01J 3/00 (2006.01); G01N 33/70 (2006.01); G01N 33/68 (2006.01); G01J 3/42 (2006.01)
CPC G01N 33/536 (2013.01) [G01N 21/272 (2013.01); G01N 21/3151 (2013.01); G01N 21/77 (2013.01); G01N 33/721 (2013.01); G01N 35/1002 (2013.01); B01L 2300/0663 (2013.01); G01J 3/00 (2013.01); G01J 3/10 (2013.01); G01J 3/42 (2013.01); G01N 21/82 (2013.01); G01N 33/6827 (2013.01); G01N 33/70 (2013.01); G01N 33/726 (2013.01); G01N 2021/3129 (2013.01); G01N 2021/3148 (2013.01); G01N 2021/825 (2013.01); G01N 2201/061 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An analyzer, comprising:
a housing surrounding space sized and configured to receive a test cartridge;
a test cartridge within the test cartridge space, the test cartridge containing-reagents mixture, contained with the test cartridge and configured to undergo an immunotype reaction, the liquid test sample-reagents mixture having a plurality of reagents;
a first light source generating a first beam of light passing through the test cartridge space, the first beam of light having a first wavelength range;
a second light source generating a second beam of light passing through the test cartridge space, the second beam of light having a second wavelength range different from the first wavelength range;
a third light source generating a third beam of light passing through the test cartridge space, the third beam of light having a third wavelength range different from the first and second wavelength range;
at least one sample detector positioned to receive one or more of the first, second and third beams of light subsequent to the first, second and third beams of light passing through the test cartridge space to generate first, second and third signals, wherein the first, second and third signals are absorption readings;
a computer system having a processor with a non-transitory computer readable medium storing a set of computer executable instructions for running on a processor that when executed cause the processor to:
receive the first, second, and third signal indicative of absorption readings captured by the sample detector at first, second and third instants of time from the first, second and third light sources and to use the first, second, and third signals indicative of absorption readings with calibration data to simultaneously determine an amount of a first analyte and a second analyte simultaneously present within the liquid test sample reagents mixture; and
a cartridge holder configured to mate with and support the test cartridge; the cartridge holder configured to rotate between a first position wherein the cartridge holder and the test cartridge are positioned to pass light from the first light source and the second light source to the sample detector, and a second position wherein the cartridge holder and the test cartridge are positioned to block light from the first light source and the second light source to the sample detector.