US 11,668,638 B2
Systems and methods for continuous sorting of cells based on molecular adhesion
Todd Sulchek, Atlanta, GA (US); Alexander Alexeev, Atlanta, GA (US); and Bushra Tasadduq, Atlanta, GA (US)
Assigned to Georgia Tech Research Corporation, Atlanta, GA (US)
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
Filed on Feb. 4, 2022, as Appl. No. 17/650,033.
Application 17/650,033 is a continuation of application No. 16/348,520, granted, now 11,268,892, previously published as PCT/US2017/060662, filed on Nov. 8, 2017.
Claims priority of provisional application 62/419,534, filed on Nov. 9, 2016.
Prior Publication US 2022/0228965 A1, Jul. 21, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. B01L 3/00 (2006.01); G01N 15/10 (2006.01); G01N 1/34 (2006.01); G01N 33/50 (2006.01)
CPC G01N 15/1056 (2013.01) [B01L 3/502761 (2013.01); B01L 3/502776 (2013.01); G01N 1/34 (2013.01); G01N 33/5005 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/16 (2013.01); B01L 2400/086 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A microchannel for processing cells comprising:
an inlet configured to deliver at least one of a first portion of the cells and a second portion of the cells in the microchannel;
ridges, each ridge comprising:
a compressive surface configured to compress the cells; and
a cell adhesion entity; and
an outlet configured to remove at least one of the first portion of the cells and the second portion of the cells from the microchannel;
wherein:
each ridge is oriented at an angle of from 25 degrees to 70 degrees relative to a center axis of the microchannel;
the cell adhesion entity is configured such that the first portion of the cells has a first adhesion property relative to the cell adhesion entity to follow a first trajectory through the microchannel;
the cell adhesion entity is further configured such that the second portion of the cells has a second adhesion property relative to the cell adhesion entity to follow a second trajectory through the microchannel; and
the first trajectory is different from the second trajectory.