	US 11,667,977 B2
	Method of using a medication or a food supplement with lactobacillus strains isolated from kimere for strengthining the immune system
Jurgen Schrezenmeir, Karlsruhe (DE); and Knut Heller, Kiel (DE)
Filed by Jurgen Schrezenmeir, Karlsruhe (DE); and Knut Heller, Kiel (DE)
Filed on May 11, 2015, as Appl. No. 14/708,942.
Application 14/708,942 is a division of application No. 13/390,210, abandoned, previously published as PCT/DE2010/000953, filed on Aug. 11, 2010.
Claims priority of application No. 102009037089.7 (DE), filed on Aug. 11, 2009.
Prior Publication US 2016/0074442 A1, Mar. 17, 2016
Int. Cl. A61P 9/12 (2006.01); C12Q 1/689 (2018.01); A23L 33/135 (2016.01); A61K 35/747 (2015.01)

CPC C12Q 1/689 (2013.01) [A23L 33/135 (2016.08); A61K 35/747 (2013.01); A23V 2002/00 (2013.01); A23Y 2220/35 (2013.01); A23Y 2220/67 (2013.01)]

4 Claims

1. A method of strengthening the immune system in a human comprising: administering a composition comprising one or more isolated bacterial strains from Kimere to a human orally, wherein the isolated bacterial strains are strains of Lactobacillus fermentum and/or Lactobacillus plantarum, and wherein the administration of the composition provides an immunomodulating effect in the human, wherein the one or more strains are selected from:

Lactobacillus fermentum K1-Lb1 (deposition number DSM 22837), or

Lactobacillus plantarum K4-Lb6 (deposition number DSM 22830),

wherein the administration of K1-Lb1 or K4-Lb6 changes the Th1/Th2 balance towards Th1;

Lactobacillus fermentum K7-Lb1(deposition number DSM 22831), or

Lactobacillus fermentum K8-Lb1 (deposition number DSM 22832),

wherein the administration of K7-Lb1 or K8-Lb1 changes the Th1/Th2 balance towards Th2, or

Lactobacillus fermentum K2-Lb6 (deposition number DSM 22829),

Lactobacillus fermentum K11-Lb3 (deposition number DSM 22838),

wherein the administration of K2-Lb6 or K11-Lb3 increased the release of defensin from intestinal cell.