US 11,667,974 B2
Diagnostic, prognostic and therapeutic uses of long noncoding RNAs for pathologies and toxicities inducing heart disorders
Hueseyin Firat, Huningue (FR); Sabrina Danilin, Riedisheim (FR); Yvan Devaux, Zoufftgen (FR); Lu Zhang, Metz (FR); Przemyslaw Leszek, Warsaw (PL); Eric Schordan, Wentzwiller (FR); Samir Ounzain, Lausanne (CH); and Thierry Pedrazzini, Lausanne (CH)
Assigned to FIRALIS SA, Huningue (FR); LUXEMBOURG INSTITUTE OF HEALTH, Luxembourg (LU); THE UNIVERSITY HOSPITAL OF LAUSANNE, Lausanne (CH); and THE CARDINAL STEFA WUSZYNSKI INSTITUTE OF CARDIOLOGY, Warsaw (PL)
Appl. No. 16/622,059
Filed by Firalis SA, Huningue (FR); Luxembourg Institute of Health, Luxembourg (LU); The University Hospital of Lausanne, Lausanne (CH); and The Cardinal Stefan Wyszynski Institute of Cardiology, Warsaw (PL)
PCT Filed Jun. 12, 2018, PCT No. PCT/EP2018/065492
§ 371(c)(1), (2) Date Dec. 12, 2019,
PCT Pub. No. WO2018/229046, PCT Pub. Date Dec. 20, 2018.
Claims priority of provisional application 62/518,418, filed on Jun. 12, 2017.
Prior Publication US 2021/0189491 A1, Jun. 24, 2021
Int. Cl. C12Q 1/6883 (2018.01); C12Q 1/686 (2018.01)
CPC C12Q 1/6883 (2013.01) [C12Q 1/686 (2013.01); C12Q 2600/178 (2013.01)] 16 Claims
 
1. A method of detecting a level of expression of one or more lncRNAs in a subject, the method comprising
(a) obtaining a biological sample from said subject; and
(b) detecting the level of expression of one or more lncRNAs in the sample, wherein the one or more lncRNAs comprise 20 lncRNAs of SEQ ID NO: 0190, SEQ ID NO: 0359, SEQ ID NO: 0776, SEQ ID NO: 1421, SEQ ID NO: 1795, SEQ ID NO: 0477, SEQ ID NO: 1511, SEQ ID NO: 0435, SEQ ID NO: 1418, SEQ ID NO: 1025, SEQ ID NO: 0265, SEQ ID NO: 1311, SEQ ID NO: 2540, SEQ ID NO: 2323, SEQ ID NO: 3011, SEQ ID NO: 2447, SEQ ID NO: 2863, SEQ ID NO: 2697, SEQ ID NO: 3128, and SEQ ID NO: 2265.