CPC C12N 15/113 (2013.01) [A61K 48/005 (2013.01); C12P 21/00 (2013.01)] | 20 Claims |
1. A nucleic acid molecule comprising a first nucleotide sequence which comprises from its 5′ end to its 3′ end:
i) a TC-rich nucleotide sequence comprising at least 12 consecutive C or T nucleotides,
ii) 4 A-rich nucleotide sequences comprising at least 5 consecutive A nucleotides,
iii) a GT-rich nucleotide sequence comprising at least 12 nucleotides, at least 80% of which are G or T nucleotides, and
iv) a an intron sequence comprising at least splice sites required for splicing of the intron sequence,
wherein the first nucleotide sequence has at least 90% sequence identity with SEQ ID NO: 2.
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