CPC C12N 5/0667 (2013.01) [A61K 35/28 (2013.01); C12N 5/0653 (2013.01); C12N 15/85 (2013.01); G01N 33/5073 (2013.01); C12N 2510/04 (2013.01); G01N 2500/10 (2013.01)] | 13 Claims |
1. An implantable construct comprising:
a scaffold; and
a human neonatal brown adipose tissue differentiated cell derived from an isolated human neonatal brown adipose tissue stem cell;
wherein the isolated human neonatal brown adipose tissue stem cell is grown in a culture medium comprising fibronectin type III domain-containing protein 5 (FNDC5) and differentiates into the human neonatal brown adipose tissue differentiated cell; and
wherein UCP-1, ELOVL3, and PGC1A gene expression is upregulated in the human neonatal brown adipose tissue differentiated cell.
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