CPC C07K 16/2803 (2013.01) [G01N 33/57492 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); G01N 2333/70503 (2013.01)] | 22 Claims |
1. A chimeric or a recombinant antibody (Ab) or an antigen binding fragment thereof capable of specifically binding to a human Lymphocyte-Activation Gene 3 (LAG-3) polypeptide, comprising:
a heavy chain variable region comprising:
the three CDR1, CDR2 and CDR3 complementarity determining regions (CDRs) of SEQ ID NO:2, or CDR1 amino acid (aa) residues 25-32, CDR2 aa residues 50-56, and CDR3 aa residues 95-101, of SEQ ID NO:2; and
a light chain variable region comprising:
the three CDR1, CDR2 and CDR3 complementarity determining regions (CDRs) of SEQ ID NO:3, or CDR1 amino acid (aa) residues 27-34, CDR2 aa residues 52-54, and CDR3 aa residues 91-102, of SEQ ID NO:3.
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