CPC C07K 16/28 (2013.01) [A61K 39/001132 (2018.08); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01)] | 59 Claims |
1. An antibody or fragment thereof that binds human beta-klotho, wherein the antibody or fragment thereof comprises: a heavy chain variable region (VH) comprising a VH complementarity determining region (CDR)1 comprising the amino acid sequence of SEQ ID NO:32, a VH CDR2 comprising the amino acid sequence of SEQ ID NO:29, and a VH CDR3 comprising the amino acid sequence of SEQ ID NO:3; and a light chain variable region (VL) comprising a VL CDR1 comprising the amino acid sequence of SEQ ID NO:4, a VL CDR2 comprising the amino acid sequence of SEQ ID NO:13, and a VL CDR3 comprising the amino acid sequence of SEQ ID NO:6.
|