Jeonghoon Sun, San Francisco, CA (US); Wei-Hsien Ho, Belmont, CA (US); Muhammad A. Alhawagri, San Francisco, CA (US); Philip Ling Kong, San Francisco, CA (US); Herve Rhinn, San Francisco, CA (US); Hua Long, San Carlos, CA (US); Karpagam Srinivasan, San Jose, CA (US); Ananya Mitra, Menlo Park, CA (US); Daniel P. Bermingham, San Francisco, CA (US); Klaus-Dieter Heger, San Mateo, CA (US); Santiago Viveros Salazar, San Carlos, CA (US); Francesca Cignarella, South San Francisco, CA (US); Ilaria Tassi, San Francisco, CA (US); Tina Schwabe, San Francisco, CA (US); Angie Grace Yee, San Francisco, CA (US); and Arnon Rosenthal, Woodside, CA (US)
Assigned to Alector LLC, South San Francisco, CA (US)
Filed by Alector LLC, South San Francisco, CA (US)
Filed on Jul. 30, 2020, as Appl. No. 16/943,123.
Claims priority of provisional application 63/057,142, filed on Jul. 27, 2020.
Claims priority of provisional application 62/960,606, filed on Jan. 13, 2020.
Claims priority of provisional application 62/947,449, filed on Dec. 12, 2019.
Claims priority of provisional application 62/892,467, filed on Aug. 27, 2019.
Claims priority of provisional application 62/881,187, filed on Jul. 31, 2019.
Prior Publication US 2021/0079074 A1, Mar. 18, 2021
1. An isolated antibody that binds to a MS4A4A protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises: an HVR-H1 comprising an amino acid sequence of SEQ ID NO:308; an HVR-H2 comprising an amino acid sequence of SEQ ID NO:309; and an HVR-H3 comprising an amino acid sequence of SEQ ID NO:310; and the light chain variable region comprises: an HVR-L1 comprising an amino acid sequence of SEQ ID NO:314; an HVR-L2 comprising an amino acid sequence of SEQ ID NO:315; and an HVR-L3 comprising an amino acid sequence of SEQ ID NO:316.