CPC C07K 14/505 (2013.01) [A61K 47/26 (2013.01); A61K 47/60 (2017.08); A61P 7/06 (2018.01); A61K 38/00 (2013.01)] | 10 Claims |
1. An erythropoietin (EPO) polypeptide comprising the amino acid sequence of SEQ ID NO: 13 except for the presence of at least one N-linked glycosylation site not present in SEQ ID NO: 13, wherein the N-linked glycosylation site consists of the sequence asparagine-xaa-serine or asparagine-xaa-threonine, wherein xaa is any amino acid except proline, and wherein one N-linked glycosylation site does not overlap with another N-linked glycosylation site, and wherein each of the at least one N-linked glycosylation site is present at a position selected from the group consisting of positions 21-23, 29-31, 34-36, 35-37, 53-55, 56-58, 65-67, 66-68, 71-73, 72-74, 73-75, 86-88, 87-89, 111-113, 114-116, 115-117, 116-118, 117-119, 118-120, 119-121, 120-122, 121-123, 122-124, 123-125, 135-137, 136-138, 158-160, and 162-164 of SEQ ID NO: 13.
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