US 11,667,661 B2
Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same
Taisun Kim, Chuncheon-si (KR); Keumsoo Song, Chuncheon-si (KR); and Junghun Kim, Seoul (KR)
Assigned to BIOMETRIX TECHNOLOGY INC, Chuncheon-si (KR)
Filed by BIOMETRIX TECHNOLOGY INC, Chuncheon-si (KR)
Filed on Mar. 8, 2021, as Appl. No. 17/195,425.
Claims priority of application No. 10-2020-0038673 (KR), filed on Mar. 30, 2020; and application No. 10-2020-0125942 (KR), filed on Sep. 28, 2020.
Prior Publication US 2021/0300959 A1, Sep. 30, 2021
Int. Cl. C07H 15/26 (2006.01); A61P 35/00 (2006.01)
CPC C07H 15/26 (2013.01) [A61P 35/00 (2018.01)] 11 Claims
 
1. A benzimidazole carbamate-sugar compound conjugate compound represented by the following Chemical Formula 1:

OG Complex Work Unit Chemistry
wherein, R1 is a sugar-compound residue, wherein the sugar compound is selected from tetrose aldose, pentose aldose, hexose aldose, tetrose ketose, pentose ketose, hexose ketose, their oxides (CHO is converted to —COOH), deoxy derivatives (—OH is converted to —H), amino sugars (—OH is converted to —NH), glycosides, disaccharides or polysaccharides thereof,
R2 and R3 are the same as or different from each other and represent hydrogen, a substituted hydrocarbon group, an alkyl group having 1 to 10 carbon atoms, or an aryl group or a heteroaryl group having 3 to 10 ring atoms, wherein the alkyl group, aryl group, or heteroaryl group is substituted with a substituent selected from halogen, cyano, hydroxy, thiol, amino, alkyl, alkyloxy, alkylamino, dialkylamino, aryl, aryloxy, arylamino, diarylamino or heteroaryl groups, and
X is selected from the group consisting of —O—, —S—, —SO—, —SO2—, —NH—, —N(R2)—, —CH2—, —CH(R2)—, and —CO—.