US 11,667,658 B2
Chemical synthesis of the organoarsenical antibiotic arsinothricin
Barry P. Rosen, Boynton Beach, FL (US); Masafumi Yoshinaga, Doral, FL (US); Stanislaw F. Wnuk, Miami, FL (US); Md Abu Hasan Howlader, Miami, FL (US); and Sk Md Sazzad Hossain Suzol, Philadelphia, PA (US)
Assigned to The Florida International University Board of Trustees, Miami, FL (US)
Filed by Barry P. Rosen, Boynton Beach, FL (US); Masafumi Yoshinaga, Doral, FL (US); Stanislaw F. Wnuk, Miami, FL (US); Md Abu Hasan Howlader, Miami, FL (US); and Sk Md Sazzad Hossain Suzol, Philadelphia, PA (US)
Filed on Dec. 5, 2022, as Appl. No. 18/74,835.
Application 18/074,835 is a division of application No. 17/363,993, filed on Jun. 30, 2021, granted, now 11,518,775.
Prior Publication US 2023/0093812 A1, Mar. 30, 2023
Int. Cl. C07F 9/72 (2006.01)
CPC C07F 9/72 (2013.01) 20 Claims
 
1. A method for synthesizing racemic arsinothricin (D,L-AST) comprising mixing 2-chloroethyl(methyl)arsinic acid with a malonate compound in the presence of a base; and adding an acid.
 
10. A method for synthesizing racemic arsinothricin (D,L-AST) comprising: mixing 2-hydroxyethyl(methyl)arsinic acid with a halogen donor; adding a malonate compound with a base; and adding an acid.