CPC C07D 491/22 (2013.01) | 31 Claims |
1. A compound of Formula (I), or an enantiomer, a mixture of enantiomers, or a tautomer thereof, or a pharmaceutically acceptable salt thereof:
wherein
Q is CH;
Z is CR5;
X is a 5-membered heteroarylene selected from the group consisting of
wherein * indicates the point of attachment of X to the methylene group bonded to X and Y;
Y is a 5- membered heteroarylene selected from the group consisting of
wherein * indicates the point of attachment of Y to the methylene group bonded to X and Y;
R1 is selected from the group consisting of H, methyl, and hydroxymethyl;
each instance of R2 is independently selected from the group consisting of H, CN, halo, C1-4 alkoxy, C1-4 alkyl, halo-C1-4 alkyl, C3-4 cycloalkylmethyl, C3-6 cycloalkyl, and C3-6 heterocyclyl;
each instance of R3 is independently selected from the group consisting of H, halo, CN, C1-4 alkoxy, halo-C1-4 alkyl, and C1-4 alkyl; and
each of R4 and R5 is independently H or F.
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