US 11,667,646 B2
Solid state forms of rucaparib and of rucaparib salts
Dijana S. Samec, Jastrebarsko (HR); Jasna Dogan, Petrinja (HR); Tomislav Biljan, Krizevci (HR); Maja M. Skugor, Zagreb (HR); Moris Mihovilovic, Pula (HR); Tina Mundorfer, Zagreb (HR); Nikolina Janton, Jakovlje (HR); Mihaela Tuksar, Cakovec (HR); Sara M. Pipercic, Novi Marof (HR); and Nea Baus Topic, Rijeka (HR)
Assigned to ASSIA CHEMICAL INDUSTRIES LTD., Petach Tikva (IL)
Filed by ASSIA CHEMICAL INDUSTRIES LTD., Petach Tikva (IL)
Filed on Dec. 15, 2020, as Appl. No. 17/122,022.
Application 17/122,022 is a continuation of application No. 16/478,509, granted, now 10,875,870, previously published as PCT/US2018/014782, filed on Jan. 23, 2018.
Claims priority of provisional application 62/449,705, filed on Jan. 24, 2017.
Claims priority of provisional application 62/465,492, filed on Mar. 1, 2017.
Claims priority of provisional application 62/503,641, filed on May 9, 2017.
Claims priority of provisional application 62/530,359, filed on Jul. 10, 2017.
Claims priority of provisional application 62/532,062, filed on Jul. 13, 2017.
Claims priority of provisional application 62/536,033, filed on Jul. 24, 2017.
Claims priority of provisional application 62/573,263, filed on Oct. 17, 2017.
Claims priority of provisional application 62/589,670, filed on Nov. 22, 2017.
Claims priority of application No. 201811000359 (IN), filed on Jan. 3, 2018.
Prior Publication US 2021/0094962 A1, Apr. 1, 2021
Int. Cl. C07D 487/06 (2006.01); A61K 31/55 (2006.01); A61P 35/00 (2006.01)
CPC C07D 487/06 (2013.01) [C07B 2200/13 (2013.01)] 16 Claims
 
1. A crystalline form of Rucaparib Hemi-Edisylate designated as Form III, characterized by data selected from one or more of the following:
a) an X-ray powder diffraction pattern substantially as depicted in FIG. 25;
b) an X-ray powder diffraction pattern having peaks at 7.1, 17.2, 21.3, 21.8 and 23.5 degrees 2-theta ±0.2 degrees 2-theta; and
c) combinations of these data.