CPC C07D 487/04 (2013.01) [C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 498/22 (2013.01); C07D 513/14 (2013.01); C07D 519/00 (2013.01)] | 19 Claims |
1. A compound according to the formula
wherein
X is selected from CH2, O, S, S(O), S(O)2 and NRa;
Ra is for each occurrence selected from hydrogen, C1-6 alkyl and C1-6 acyl;
Y1, Y2 and Y3 are independently selected from the group consisting of N, N(Ra), O, C(Rb)1-2 and C═O;
Rb is selected from hydrogen, C1-6 alkyl and halo;
Z is C(Rc) or NRc;
Rc is a C1-4 unsaturated carbon chain optionally substituted with one or more R1 groups, optionally interrupted by 1 or 2 heteroatoms selected from O, N and S;
Rz is N, CH or C(R1) and together with ZRc and the carbon to which they are bound form a 5- or 6-membered heteroaryl or 6-membered aryl ring substituted with m R1 groups;
R1 is a linker-R6 group, wherein the linker is a bond, (C1-C4) alkanyl, (C2-C4) alkenyl or (C2-C4) alkynyl, optionally substituted by one or more Rb and R6 is Re, —C(Rf)3, or —C(Rf)═C(Rf)2;
R2 is Ra;
ring B is 5-10-membered heteroaryl;
R3 is, for each occurrence, independently selected from Rb and ORa;
L is O, NRa or alkylene;
W is 5-10 membered aryl or heteroaryl optionally substituted by p R4;
R4 is for each occurrence selected from Rb and ORa;
Rd is for each occurrence independently selected from hydrogen, C1-6 alkyl, aralkyl, C5-10 aryl or heteroaryl, or two Rd together with a nitrogen to which they are both attached form a C3-10heterocyclic group optionally substituted by one or more Re;
Re is independently for each occurrence halo, —ORd, —SRd, —S(O)2Rd, —NRdRd, —Si(Ra)3, —C(O)OH, —C(O)ORa, or —C(O)NRdRd;
Rf is independently for each occurrence Ra, Rb, or Re, or two Rf groups together with the carbon atom bound thereto provide a C3-6 cycloalkyl group or a C3-10heterocyclic group each optionally substituted with one or more Re;
m is 1, 2, 3, or 4;
n is 0, 1 or 2; and
p is 0, 1, 2, 3, 4, or 5.
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