US 11,667,632 B2
2-(1H-indazol-3-yl)-3H-imidazo[4,5-C]pyridines and their anti-inflammatory uses thereof
John Hood, Del Mar, CA (US); David Mark Wallace, San Diego, CA (US); Sunil Kumar KC, San Diego, CA (US); Yusuf Yazici, La Jolla, CA (US); Christopher Swearingen, San Marcos, CA (US); and Luis A Dellamary, San Marcos, CA (US)
Assigned to BioSplice Therapeutics, Inc., San Diego, CA (US)
Filed by BioSplice Therapeutics, Inc., San Diego, CA (US)
Filed on Dec. 4, 2020, as Appl. No. 17/112,282.
Application 17/112,282 is a continuation of application No. 15/773,737, granted, now 10,899,757, previously published as PCT/US2016/060856, filed on Nov. 7, 2016.
Claims priority of provisional application 62/303,168, filed on Mar. 3, 2016.
Claims priority of provisional application 62/252,332, filed on Nov. 6, 2015.
Prior Publication US 2021/0292319 A1, Sep. 23, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/444 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); C07D 471/04 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 9/00 (2006.01)
CPC C07D 471/04 (2013.01) [A61K 9/0019 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61P 19/02 (2018.01); A61P 29/00 (2018.01); C07B 2200/13 (2013.01)] 8 Claims
 
1. A method of treating inflammation associated with osteoarthritis in a subject in need thereof, the method comprising administering to the subject a composition comprising a compound of Formula (I)

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof,
wherein the compound of Formula (I) is present in the composition as a polymorph of Form 9 and has an X-ray powder diffraction pattern comprising peaks at °2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.