CPC C07D 417/06 (2013.01) [A61K 49/0017 (2013.01); A61K 49/0021 (2013.01); C07D 277/64 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07D 417/14 (2013.01); C07F 7/1804 (2013.01)] | 26 Claims |
1. A method for imaging tau proteins that accumulate in the brain, the method comprising the steps of:
(a) administering to a mammal an effective amount of a compound of the Formula (I), or a pharmaceutically acceptable salt or a solvate thereof, and
(b) imaging the brain of the mammal,
wherein the compound of Formula (I) is:
wherein:
R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;
R3 is hydrogen or halogen;
ring A is a benzene ring or a pyridine ring;
ring B is selected from the group consisting of the following formulae (i), (ii), (iii), and (iv):
in the formula (ii), Ra is alkyl;
R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and
represents a double bona or a triple bond,
wherein the compound of Formula (I) is not:
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