CPC C07D 401/04 (2013.01) [C07C 233/20 (2013.01); C07C 233/21 (2013.01); C07D 209/12 (2013.01); C07D 333/64 (2013.01); C07D 409/14 (2013.01)] | 24 Claims |
1. A compound of formula (I):
wherein:
TL is chosen from:
L is selected from divalent (C3-C7)hydrocarbyl, (C2-C10)oxaalkyl, and (C2-C10)azaalkyl;
DG is selected from:
R20 and R21 are independently a (C1-C12)hydrocarbyl, or, taken together along with the carbon to which they are attached, R20 and R21 optionally combine to form a (C3-C12)carbocyclyl;
substructure
as drawn above, represents either
wherein:
J is selected from: S, O, and NR17, and, G is C when
and
J is C—R16 and G is N
when
Y is —O— or —CH2—;
represents either a single or a double bond connecting a carbon atom to G′;
G′ is CH or N when
is a single bond, or, G′ is C when
is a double bond;
R1 is selected from H and (C1-C3)alkyl;
R2 is
or optionally substituted (C1-C15)hydrocarbyl, wherein the optional substituents for (C1-C15)hydrocarbyl are selected from halo and (C1-C3)perfluoroalkyl;
R5 and R6 are selected from H and (C1-C3)alkyl;
R7 is selected from any of the sidechains present in naturally-occurring α-amino acids;
R8 is H or (C1-C3)alkyl;
R9 is chosen from H, (C1-C3)alkyl, or —C(═O)—O—(C1-C6)alkyl;
R13 and R14 are selected from H and (C1-C3)alkyl;
R15 is
and
R16 and R17 are selected from: H and (C1-C6)alkyl;
with the proviso that the compound is not:
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24. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound according to claim 1.
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