CPC C07D 267/10 (2013.01) [A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01)] | 15 Claims |
1. A method for treating alpha-1 antitrypsin deficiency in a patient in need thereof, comprising, administering to the patient, an effective amount of a compound of formula (I)
or a pharmaceutically acceptable salt thereof, wherein,
R1 is
R2 is selected from hydrogen, F, Cl, Br, OSO2C1-3alkyl, or C1-3alkyl;
R3 is selected from hydrogen, F, Cl, Br, CN, CF3, SO2C1-3alkyl, CONH2 or SO2NR4R5, wherein R4 and R5 together with the nitrogen atom to which they are attached form an azetidine, pyrrolidine or piperidine ring; or
R1 is selected from
X is selected from O, S or CF2;
Y is selected from O or S;
Q is selected from CH or N;
R6 is selected from C1-3alkyl, wherein said C1-3alkyl is optionally substituted by 1, 2 or 3 F and optionally by one substituent selected from OH, OC1-3alkyl, N(C1-3alkyl)2, cyclopropyl, or tetrahydropyran; and
R7 is selected from hydrogen, F, Cl or CH3.
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