US 11,667,614 B2
Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof
Pankaj Vasudev Parmar, Vadodara (IN); Raja Jeyakumar John Muthiah, Vadodara (IN); Vikas Kantilal Chauhan, Vadodara (IN); and Jagdish Kanjibhai Solanki, Vadodara (IN)
Assigned to Navinta III Inc., Boca Raton, FL (US)
Filed by Navinta III Inc, Boca Raton, FL (US)
Filed on Apr. 13, 2022, as Appl. No. 17/720,007.
Claims priority of provisional application 63/176,029, filed on Apr. 16, 2021.
Prior Publication US 2022/0332688 A1, Oct. 20, 2022
Int. Cl. C07D 265/26 (2006.01)
CPC C07D 265/26 (2013.01) 20 Claims
 
1. A process for the preparation of Salcaprozic Acid or a pharmaceutically acceptable salt thereof, comprising:
a. hydrolyzing a compound of formula II:

OG Complex Work Unit Chemistry
wherein, R is straight or branched chain alkyl
in the presence of benzotriazole, hydrazine, sodium borohydride or mixture thereof; and
b. isolating Salcaprozic Acid, which is free from colored impurity.