US 11,667,604 B2
Phenyl containing compound, intermediate thereof, preparation method therefor and application thereof
Jun He, Shanghai (CN); Zhefeng Wang, Shanghai (CN); Yuezhu Zhao, Shanghai (CN); Yani Yang, Shanghai (CN); Qinghui Fu, Shanghai (CN); Wei Bian, Shanghai (CN); Yuan Zhao, Shanghai (CN); Chen Ge, Shanghai (CN); Yue Zhang, Shanghai (CN); Bing Yi, Shanghai (CN); Minghao Niu, Shanghai (CN); and Jiuhui Zhang, Shanghai (CN)
Assigned to SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD., Shanghai (CN); and SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, Shanghai (CN)
Appl. No. 17/627,965
Filed by SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD., Shanghai (CN); and SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, Shanghai (CN)
PCT Filed Jul. 14, 2020, PCT No. PCT/CN2020/101842
§ 371(c)(1), (2) Date Jan. 18, 2022,
PCT Pub. No. WO2021/008516, PCT Pub. Date Jan. 21, 2021.
Claims priority of application No. 201910650358.1 (CN), filed on Jul. 18, 2019.
Prior Publication US 2022/0274920 A1, Sep. 1, 2022
Int. Cl. C07C 309/18 (2006.01); A61K 9/107 (2006.01); A61K 31/337 (2006.01); A61K 47/20 (2006.01); A61P 35/04 (2006.01)
CPC C07C 309/18 (2013.01) [A61K 9/1075 (2013.01); A61K 31/337 (2013.01); A61K 47/20 (2013.01); A61P 35/04 (2018.01)] 9 Claims
 
1. A compound of formula I or a pharmaceutically acceptable salt thereof,

OG Complex Work Unit Chemistry
wherein, R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy or C(═O)OR8; wherein R8 is C1-C4 alkyl;
R6 is

OG Complex Work Unit Chemistry
R7 is —OH, —NH2, —NHCH3, —N(CH3)2 or C1-4 alkoxy.