US 11,666,750 B2
Adaptive deep brain stimulation using homeostatic window
Scott R. Stanslaski, Shoreview, MN (US); Thomas Adamski, Andover, MN (US); Duane L. Bourget, Andover, MN (US); Timothy J. Denison, Oxford (GB); Benjamin P. Isaacson, Centerville, MN (US); Eric J. Panken, Edina, MN (US); and Jeffrey Herron, Minneapolis, MN (US)
Assigned to Medtronic, Inc., Minneapolis, MN (US)
Filed by Medtronic, Inc., Minneapolis, MN (US)
Filed on Nov. 30, 2020, as Appl. No. 17/107,257.
Application 17/107,257 is a division of application No. 15/714,845, filed on Sep. 25, 2017, granted, now 10,864,368.
Claims priority of provisional application 62/400,605, filed on Sep. 27, 2016.
Prior Publication US 2021/0093851 A1, Apr. 1, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61B 5/00 (2006.01); A61B 5/24 (2021.01); A61N 1/372 (2006.01); A61N 1/04 (2006.01)
CPC A61N 1/0534 (2013.01) [A61B 5/24 (2021.01); A61B 5/4836 (2013.01); A61B 5/4848 (2013.01); A61B 5/686 (2013.01); A61B 5/6868 (2013.01); A61N 1/36064 (2013.01); A61N 1/36067 (2013.01); A61N 1/36071 (2013.01); A61N 1/36082 (2013.01); A61N 1/36132 (2013.01); A61N 1/36135 (2013.01); A61N 1/36139 (2013.01); A61N 1/37247 (2013.01); A61B 5/0002 (2013.01); A61N 1/0476 (2013.01); A61N 1/36014 (2013.01); A61N 1/36096 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for delivering electrical stimulation therapy to a patient, the method comprising:
delivering electrical stimulation therapy to tissue of a patient via electrodes; and
adjusting a level of at least one parameter of the electrical stimulation therapy such that a sensed signal indicative of a gamma signal of a brain of the patient is not less than a lower bound and not greater than an upper bound of a range;
wherein the upper bound is one of:
a magnitude of the sensed signal while receiving a first level of the electrical stimulation therapy that is a minimum level sufficient to reduce one or more symptoms of a disease and while the patient is receiving medication for reduction of one or more symptoms of the disease or disorder; or
a magnitude of the sensed signal while receiving a second level of the electrical stimulation therapy sufficient to cause maximum reduction of the one or more symptoms of the disease or disorder without inducing substantial side effects in the patient and while the patient is not receiving the medication for reduction of the one or more symptoms of the disease; and
wherein the lower bound is one of:
a magnitude of the sensed signal while receiving a third level of the electrical stimulation therapy that is a minimum level sufficient to reduce the one or more symptoms of the disease and while the patient is not receiving the medication for reduction of the one or more symptoms of the disease; or
a magnitude of the sensed signal while receiving a fourth level of the electrical stimulation therapy, while the patient is not receiving the medication for reduction of the one or more symptoms of the disease, that is sufficient to reduce the one or more symptoms of the disease or disorder but which above the level, substantially no further substantial reduction in the one or more symptoms is achieved.