US 11,666,691 B2
Bioartificial ultrafiltration device and methods related thereto
Shuvo Roy, San Ramon, CA (US); Rishi Kant, Foster City, CA (US); Andrew Posselt, Mill Valley, CA (US); Shang Song, Redwood City, CA (US); Willieford Moses, Oakland, CA (US); and Charles Blaha, San Francisco, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Jun. 9, 2021, as Appl. No. 17/343,361.
Application 17/343,361 is a continuation of application No. 16/082,501, granted, now 11,033,668, previously published as PCT/US2017/021196, filed on Mar. 7, 2017.
Claims priority of provisional application 62/328,298, filed on Apr. 27, 2016.
Claims priority of provisional application 62/304,758, filed on Mar. 7, 2016.
Prior Publication US 2022/0016324 A1, Jan. 20, 2022
Int. Cl. A61M 1/16 (2006.01); B01D 63/08 (2006.01); B01D 67/00 (2006.01); B01D 69/02 (2006.01); B01D 69/12 (2006.01); B01D 71/02 (2006.01); A61M 1/36 (2006.01); B01D 69/08 (2006.01); A61B 5/15 (2006.01); B01D 61/14 (2006.01); B01D 71/70 (2006.01); B01D 69/14 (2006.01)
CPC A61M 1/1678 (2013.01) [A61B 5/150992 (2013.01); A61M 1/3689 (2014.02); B01D 61/145 (2013.01); B01D 63/08 (2013.01); B01D 67/0037 (2013.01); B01D 67/0072 (2013.01); B01D 69/02 (2013.01); B01D 69/08 (2013.01); B01D 69/12 (2013.01); B01D 71/027 (2013.01); A61M 2202/09 (2013.01); A61M 2205/04 (2013.01); B01D 69/145 (2013.01); B01D 71/024 (2013.01); B01D 71/70 (2013.01); B01D 2325/021 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A bioartificial ultrafiltration device comprising:
a first planar scaffold and a second planar scaffold each comprising a matrix comprising a population of cells and a plurality of channels adjacent the population of cells, wherein the channels extend from a first surface to a second surface of each of the planar scaffolds;
a first semipermeable ultrafiltration membrane disposed on the first surface of the first and second planar scaffolds;
a first compartment adjacent to and sandwiched between the first surface of the first and second planar scaffolds and comprising an inlet and an outlet, wherein the first semipermeable ultrafiltration membrane allows transport of ultrafiltrate from the first compartment to the scaffolds;
a second compartment adjacent to the second surface of the first planar scaffold and comprising an outlet;
a third compartment adjacent to the second surface of the second planar scaffold and comprising an outlet,
wherein the first semipermeable ultrafiltration membrane comprises a plurality of pores having a width in the range of 5 nm-5 micron, and
wherein the ultrafiltrate traverses from the plurality of channels in the scaffolds into the second compartment and the third compartment.