US 11,666,663 B2
Hexameric tetrahedral RNA nanostructures
Bruce A. Shapiro, Gaithersburg, MD (US); Paul J. Zakrevsky, Frederick, MD (US); and Luc Jaeger, Goleta, CA (US)
Assigned to The United States of America,as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US); and The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/53,615
Filed by The United States of America,as represented by the Secretary,Department of Health and Human Services, Bethesda, MD (US); and The Regents of the University of California, Oakland, CA (US)
PCT Filed May 8, 2019, PCT No. PCT/US2019/031356
§ 371(c)(1), (2) Date Nov. 6, 2020,
PCT Pub. No. WO2019/217576, PCT Pub. Date Nov. 14, 2019.
Claims priority of provisional application 62/696,619, filed on Jul. 11, 2018.
Claims priority of provisional application 62/668,653, filed on May 8, 2018.
Prior Publication US 2021/0069345 A1, Mar. 11, 2021
Int. Cl. C12N 15/113 (2010.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); B82Y 5/00 (2011.01)
CPC A61K 47/6929 (2017.08) [A61K 47/549 (2017.08); B82Y 5/00 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A tetrahedral nanostructure comprising a ribonucleic acid (RNA) scaffold comprising a core, wherein the core comprises four hexameric RNA nanorings linked together, and wherein the nanostructure has a truncated tetrahedral geometry.