CPC A61K 47/6803 (2017.08) [C07K 16/22 (2013.01); C07K 16/4241 (2013.01); C12N 15/101 (2013.01); C12N 15/63 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01)] | 16 Claims |
1. A monoclonal antibody or a derivative thereof specifically binding to human plasmalemma vesicle-associated protein, comprising a first variable region and a second variable region,
wherein the first variable region is an antibody light chain variable region comprising antigen complementarity-determining regions CDR1, CDR2 and CDR3 having amino acid sequences as set forth in SEQ ID NO: 17, SEQ ID NO: 18 and SEQ ID NO: 19, respectively; and
wherein the second variable region is an antibody heavy chain variable region comprising antigen complementarity-determining regions CDR1, CDR2 and CDR3 having amino acid sequences as set forth in SEQ ID NO: 22, SEQ ID NO: 23 and SEQ ID NO: 24, respectively, and
wherein the derivative is a Fab fragment an Fv fragment a single-chain antibody, a bispecific antibody, an antibody-drug conjugate, or a chimeric antigen receptor T-cell.
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