US 11,666,654 B2
Drug delivery system for treating disease
Stephen Dimagno, Chicago, IL (US)
Assigned to SDG LLC, Cambridge, MA (US)
Appl. No. 16/759,793
Filed by OSTEOANALGESIA, LLC, Cambridge, MA (US)
PCT Filed Nov. 1, 2018, PCT No. PCT/US2018/058758
§ 371(c)(1), (2) Date Apr. 28, 2020,
PCT Pub. No. WO2019/089962, PCT Pub. Date May 9, 2019.
Claims priority of provisional application 62/581,405, filed on Nov. 3, 2017.
Prior Publication US 2020/0306380 A1, Oct. 1, 2020
Int. Cl. A61K 47/58 (2017.01); A61K 31/519 (2006.01); C08F 220/58 (2006.01)
CPC A61K 47/58 (2017.08) [A61K 31/519 (2013.01); C08F 220/58 (2013.01)] 11 Claims
 
1. A copolymer derived from N-(2-hydroxypropyl)methacrylamide and a drug loaded monomer, wherein the drug loaded monomer has a structure according to one of the following formulae:

OG Complex Work Unit Chemistry
wherein:
X is CH2, NH, N—R3, O, or S;
n is 0-8;
R1 is alkyl;
R2 is alkyl;
R3 is acetyl or CH3; and
Drug is baricitinib, ruxolitinib, tofacitinib, oclacitinib, upadacitinib, or peficitinib.