US 11,666,584 B2
Steroidal hormones for the treatment and prevention of wave burst arrhythmia
Joe-Elie Salem, Paris (FR); Christian Funck-Brentano, Paris (FR); Anne Bachelot, Paris (FR); and Xavier Waintraub, Paris (FR)
Assigned to ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, Paris (FR); INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR); and SORBONNE UNIVERSITÉ, Paris (FR)
Appl. No. 16/94,560
Filed by ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, Paris (FR); INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), Paris (FR); and SORBONNE UNIVERSITÉ, Paris (FR)
PCT Filed Apr. 18, 2017, PCT No. PCT/EP2017/059097
§ 371(c)(1), (2) Date Jul. 22, 2020,
PCT Pub. No. WO2017/182421, PCT Pub. Date Oct. 26, 2017.
Claims priority of application No. 1653468 (FR), filed on Apr. 19, 2016.
Prior Publication US 2020/0352960 A1, Nov. 12, 2020
Int. Cl. A61K 31/567 (2006.01); A61P 9/12 (2006.01); A61K 9/00 (2006.01); A61K 31/565 (2006.01); A61K 31/5685 (2006.01)
CPC A61K 31/567 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/565 (2013.01); A61K 31/5685 (2013.01); A61P 9/12 (2018.01)] 16 Claims
OG exemplary drawing
 
1. A method for treating torsades de pointes comprising administering to a patient a compound of general formula (I):

OG Complex Work Unit Chemistry
wherein
R1 is chosen from H, CH3, CH2—CH3, CH═CH2, and C≡CH;
R2 is chosen from CH3, CH2—CH3, CH═CH2, and C≡CH;
R3 is chosen from —H, —CH3, =CH2, wherein the bond between the carbon of the ring and R3 is a double bond, and ≡CH, wherein the bond between the carbon of the ring and R3 is a triple bond; and
R4 is chosen from —H, —OH and =O, wherein the bond between the carbon of the ring and R4 is a double bond;
wherein the compound of general formula (I) is chosen from levonorgestrel, norethisterone, desogestrel, etonogestrel, 19-nortestosterone, medroxyprogesterone, or medroxyprogesterone acetate.