CPC A61K 31/551 (2013.01) [A61K 47/545 (2017.08); A61K 47/65 (2017.08); A61K 47/68 (2017.08); A61P 35/00 (2018.01); A61P 37/06 (2018.01); C07K 16/2827 (2013.01); C07K 16/32 (2013.01); C12N 9/93 (2013.01); C12Y 203/02007 (2013.01)] | 22 Claims |
1. A conjugate having the chemical structure
Ab-(L1-D)p,
wherein
D is a PROTAC having the structure E3LB-L2-PB, wherein
E3LB is an E3 ligase binding group covalently bound to L2, wherein the E3 ligase is a tetrahydro-benzodiazepinone or a pharmaceutically acceptable salt thereof, and
wherein E3LB is
L2 is a linker covalently bound to E3LB and PB, and
PB is a protein binding group covalently bound to L2;
Ab is an antibody covalently bound to L1;
L1 is a linker covalently bound to Ab and D; and
p has a value from about 1 to about 8.
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