US 11,666,529 B2
Use of PRG4 to improve dynamic visual acuity and higher order aberrations
Benjamin D. Sullivan, San Diego, CA (US); and Edward R. Truitt, III, Medina, WA (US)
Assigned to Lubris LLC, Naples, FL (US)
Appl. No. 15/574,712
Filed by Lubris LLC, Framingham, MA (US)
PCT Filed May 19, 2016, PCT No. PCT/US2016/033248
§ 371(c)(1), (2) Date Nov. 16, 2017,
PCT Pub. No. WO2016/187414, PCT Pub. Date Nov. 24, 2016.
Claims priority of provisional application 62/163,753, filed on May 19, 2015.
Prior Publication US 2018/0140546 A1, May 24, 2018
Int. Cl. A61K 8/42 (2006.01); A61K 31/164 (2006.01); A61K 31/165 (2006.01); A61K 31/404 (2006.01); A61K 31/4164 (2006.01); A61K 9/70 (2006.01); A61K 8/49 (2006.01); A61K 9/06 (2006.01); A61Q 19/00 (2006.01); A61K 8/02 (2006.01); A61P 17/00 (2006.01); A61K 8/44 (2006.01); A61Q 19/08 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61P 27/02 (2006.01); A61K 38/17 (2006.01)
CPC A61K 9/0048 (2013.01) [A61K 38/1709 (2013.01); A61K 45/06 (2013.01); A61P 27/02 (2018.01)] 18 Claims
 
1. A method of treating a visual aberration due to corneal surface irregularity in an eye of a human patient comprising depositing onto the surface of the eye or of each eye of said patient an amount of 10-100 microliters of an ophthalmically acceptable solution comprising lubricin at a concentration within a range of from 10 μg/mL to 300 μg/mL to form a hydrated gel layer of lubricin across the corneal surface of the eye or of each eye, thereby to alleviate said visual aberration, wherein the visual aberration is selected from the group consisting of diminished night vision, visual halo, visual starburst, loss of static visual acuity, visual glare, and higher order aberrations.