	US 11,666,527 B2
	Biodegradable block copolymer drug delivery composition
Christophe Roberge, Jacou (FR); Anthony Rech, Jacou (FR); Jean-Manuel Cros, Jacou (FR); Myriam Abbassi, Jacou (FR); Adolfo López-Noriega, Jacou (FR); Lea Pebrel, Jacou (FR); Audrey Petit, Jacou (FR); and Juliette Serindoux, Jacou (FR)
Assigned to MEDINCELL, Jacou (FR); Christophe Roberge, Jacou (FR); Anthony Rech, Jacou (FR); and Jean-Manuel Cros, Jacou (FR)
Appl. No. 16/631,586
Filed by MEDINCELL, Jacou (FR); Christophe Roberge, Jacou (FR); Anthony Rech, Jacou (FR); and Jean-Manuel Cros, Jacou (FR)
PCT Filed Jul. 17, 2018, PCT No. PCT/EP2018/069442 § 371(c)(1), (2) Date Jan. 16, 2020, PCT Pub. No. WO2019/016236, PCT Pub. Date Jan. 24, 2019.
Claims priority of provisional application 62/533,370, filed on Jul. 17, 2017.
Prior Publication US 2020/0179518 A1, Jun. 11, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 31/167 (2006.01); A61K 31/5415 (2006.01); A61K 31/7048 (2006.01); A61K 47/34 (2017.01); C08G 63/664 (2006.01); A61K 31/445 (2006.01); A61K 31/519 (2006.01); A61K 38/12 (2006.01); A61K 9/20 (2006.01)

CPC A61K 9/0024 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0029 (2013.01); A61K 9/204 (2013.01); A61K 9/2031 (2013.01); A61K 31/167 (2013.01); A61K 31/445 (2013.01); A61K 31/519 (2013.01); A61K 31/5415 (2013.01); A61K 31/7048 (2013.01); A61K 38/12 (2013.01); A61K 47/34 (2013.01); C08G 63/664 (2013.01)]

31 Claims

1. An injectable biodegradable drug delivery composition comprising:

(i) a mixture of at least three different block copolymers, wherein each block copolymer is:

(a) a biodegradable triblock copolymer having the formula:

A_v-B_w-A_x

wherein A is a polyester and B is polyethylene glycol and v and x are the number of repeat units ranging from 1 to 3,000 and w is the number of repeat units ranging from 3 to 300 and v=x or v≠x; or

(b) a biodegradable diblock copolymer having the formula:

C_y-A_z

wherein A is a polyester and C is an end-capped polyethylene glycol and y and z are the number of repeat units with y ranging from 2 to 250 and z ranging from 1 to 3,000; and

wherein the mixture comprises at least one (a) and at least one (b); and the weight ratio of the sum of the biodegradable triblock copolymers of (a) and the sum of the biodegradable diblock copolymers of (b) is 1:19 to 5:1; and wherein for at least one of the copolymers according to (a) or (b) A is poly(lactic-co-glycolic acid) (PLGA); and

(ii) at least one pharmaceutically active ingredient; wherein the release kinetics of said at least one active ingredient from said biodegradable drug delivery composition can be modulated without adversely affecting injectability and/or viscosity before injection of the injectable biodegradable drug delivery composition and/or depot robustness after injection of the biodegradable drug delivery composition, compared to a composition having a single biodegradable triblock of the copolymer of (a) and a single biodegradable diblock of the copolymer of (b).