CPC G02B 21/0076 (2013.01) [G01N 21/6458 (2013.01); G01N 21/6486 (2013.01); G01N 21/8851 (2013.01); G02B 21/0032 (2013.01); G02B 21/367 (2013.01)] | 20 Claims |
1. A light-sheet based microscopy device comprising:
a light source;
a pair of mirrors configured to receive light from the light source and generate an array of coherent light sheets, wherein the coherent light sheets are mutually spatially incoherent from each other, and wherein the pair of mirrors is further configured to reconfigure a coherency of the coherent light sheets with respect to each other;
an encoder configured to encode the array of incoherent light sheets, the encoder comprising: a frequency modulator configured to segment the array of coherent light sheets and encode each coherent light sheet with a respective frequency; or a temporal modulator configured to segment the array of coherent light sheets by an arbitrary orthogonal encoding basis including a Hadamard basis or a random mask;
at least one lens configured to direct the encoded light sheets towards a biological sample, and
an image capturing device configured to receive a fluorescence signal from the biological sample.
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