CPC C12Q 1/6883 (2013.01) [A61K 38/1841 (2013.01); A61K 38/43 (2013.01); G01N 33/6887 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/10 (2013.01); G01N 2800/52 (2013.01)] | 5 Claims |
1. A method of treating a musculoskeletal disorder in a subject; the method comprising administering an enzymatic therapy to reduce an amount of an aggrecan-hyaluronan matrix of the subject from a treatment site in the subject to treat the musculoskeletal disorder and measuring a level of the aggrecan-hyaluronan matrix before administering the enzymatic therapy and after administering the therapy to determine a reduction in the amount of the aggrecan-hyaluronan matrix; and wherein the enzymatic therapy comprises chondrolytic biologics.
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