US 11,655,459 B2
Methods for reprogramming somatic cells
Rudolf Jaenisch, Brookline, MA (US); and Konrad Hochedlinger, Cambridge, MA (US)
Assigned to Whitehead Institute for Biomedical Research, Cambridge, MA (US)
Filed by Whitehead Institute for Biomedical Research, Cambridge, MA (US)
Filed on Aug. 29, 2022, as Appl. No. 17/898,360.
Application 12/703,061 is a division of application No. 10/997,146, filed on Nov. 24, 2004, granted, now 7,682,828, issued on Mar. 23, 2010.
Application 17/898,360 is a continuation of application No. 16/665,821, filed on Oct. 28, 2019.
Application 16/665,821 is a continuation of application No. 16/030,815, filed on Jul. 9, 2018, granted, now 10,457,917, issued on Oct. 29, 2019.
Application 16/030,815 is a continuation of application No. 15/588,062, filed on May 5, 2017, granted, now 10,017,744, issued on Jul. 10, 2018.
Application 15/588,062 is a continuation of application No. 14/923,321, filed on Oct. 26, 2015, granted, now 9,670,464, issued on Jun. 6, 2017.
Application 14/923,321 is a continuation of application No. 13/646,430, filed on Oct. 5, 2012, granted, now 9,169,490, issued on Oct. 27, 2015.
Application 13/646,430 is a continuation of application No. 12/703,061, filed on Feb. 9, 2010, granted, now 8,940,536, issued on Jan. 27, 2015.
Claims priority of provisional application 60/530,042, filed on Dec. 15, 2003.
Claims priority of provisional application 60/525,612, filed on Nov. 26, 2003.
Prior Publication US 2022/0403344 A1, Dec. 22, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/85 (2006.01); C12N 5/074 (2010.01); A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12N 15/877 (2010.01)
CPC C12N 5/0696 (2013.01) [C12N 15/85 (2013.01); A01K 67/0273 (2013.01); A01K 67/0275 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); C07K 14/4702 (2013.01); C12N 15/8509 (2013.01); C12N 15/8775 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/605 (2013.01); C12N 2506/1307 (2013.01); C12N 2510/00 (2013.01); C12N 2830/003 (2013.01); C12N 2830/006 (2013.01)] 23 Claims
 
1. A composition comprising an isolated human somatic cell that comprises an exogenously introduced nucleic acid encoding an OCT4 protein.