CPC C12N 1/20 (2013.01) [A61K 39/04 (2013.01); C07K 14/195 (2013.01); C07K 14/35 (2013.01); C12N 1/36 (2013.01); C12N 15/1031 (2013.01); C12N 15/1136 (2013.01); C12Q 1/689 (2013.01); G01N 33/5695 (2013.01); A61K 2039/522 (2013.01); A61K 2039/552 (2013.01); C12N 1/205 (2021.05); C12Q 2600/156 (2013.01); C12R 2001/32 (2021.05)] | 22 Claims |
1. A Mycobacterium mutant, comprising a mutation in a gene sequence encoding global gene regulators (GGRs), wherein the GGR is sigE, wherein the GGR gene is at least partially inactivated, wherein the Mycobacterium is selected from the group consisting of Mycobacterium avium subspecies paratuberculosis (M. ap) and Mycobacterium bovis (M. bovis).
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