CPC C07K 16/40 (2013.01) [A61K 47/6871 (2017.08); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01)] | 22 Claims |
1. An antibody or an antigen-binding portion thereof, comprising:
a heavy chain variable region comprising three complementarity determining regions, VH CDR1, VH CDR2, and VH CDR3, selected from the group consisting of (1) the amino acid sequences set forth in SEQ ID NOS: 17, 18, and 19, respectively, and (2) the amino acid sequences set forth in SEQ ID NOS: 27, 28, and 29, respectively; and
a light chain variable region comprising three complementarity determining regions, VL CDR1, VL CDR2 and VL CDR3, selected from the group consisting of (1) the amino acid sequences set forth in SEQ ID NOS: 20, 21, and 22, respectively, and (2) the amino acid sequences set forth in SEQ ID NOS: 30, 31, and 32, respectively; and
wherein the antibody or antigen-binding portion thereof specifically binds to Doublecortin-like kinase 1 (DCLK1) isoform 2 or 4.
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