	US 11,655,295 B2
	Anti-LAG-3 antibody and use thereof
Tongtong Xue, Sichuan (CN); Qiang Li, Shanghai (CN); Liang Xiao, Sichuan (CN); Yuncheng Zheng, Shanghai (CN); Dengnian Liu, Sichuan (CN); Si Chen, Shanghai (CN); Yan Hu, Sichuan (CN); Lichun Wang, Sichuan (CN); and Jingyi Wang, Sichuan (CN)
Assigned to SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Sichuan (CN)
Appl. No. 16/963,067
Filed by SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Sichuan (CN)
PCT Filed Jan. 3, 2019, PCT No. PCT/CN2019/070303 § 371(c)(1), (2) Date Jul. 17, 2020, PCT Pub. No. WO2019/141092, PCT Pub. Date Jul. 25, 2019.
Claims priority of application No. 201810050759.9 (CN), filed on Jan. 18, 2018.
Prior Publication US 2020/0347131 A1, Nov. 5, 2020
Int. Cl. C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01)

CPC C07K 16/2803 (2013.01) [A61K 39/39558 (2013.01); A61P 35/00 (2018.01)]

28 Claims

1. An antibody or antigen-binding fragment thereof which is capable of specifically binding to LAG-3, comprising:

(1) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 1;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 2;

(2) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 16;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 17;

(3) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 18;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 19;

(4) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 20;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 21;

(5) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 22;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 23;

(6) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 24;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 25; or

(7) three CDRs of the heavy chain variable region (VII) as shown in SEQ ID NO: 26;

and three CDRs of the light chain variable region (VL) as shown in SEQ ID NO: 27;

wherein, the three CDRs of the heavy chain variable region (VII) and the three CDRs of the light chain variable region (VL) are defined by the Kabat, Chothia or IMGT numbering system.