CPC C07K 16/18 (2013.01) [A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); A01K 2217/052 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); A01K 2267/0362 (2013.01); A01K 2267/0368 (2013.01); A01K 2267/0375 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01)] | 18 Claims |
1. A method of treating non-alcoholic steatohepatitis (NASH) in a subject in need thereof, the method comprising administering to the subject an antibody or a fragment thereof that specifically binds to a phosphocholine (PC) headgroup of an oxidized phospholipid, the antibody comprising: a VH comprising the complementarity determining regions (CDRs) of the VH amino acid sequence set forth in SEQ ID NO: 2; and a VL comprising the CDRs of the VL amino acid sequence set forth in SEQ ID NO: 2, wherein the VH comprises the VH amino acid sequence set forth in SEQ ID NO: 2.
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