US 11,655,213 B2
Pharmaceutically active compounds
Jason John Shiers, Nottingham (GB); John Paul Watts, Nottingham (GB); Stuart Thomas Onions, Nottingham (GB); Mohammed Abdul Quddus, Nottingham (GB); Joseph William Wrigglesworth, Nottingham (GB); Colin Peter Sambrook-Smith, Nottingham (GB); Alan Naylor, Herts (GB); and Derek Londesbrough, Sunderland (GB)
Assigned to BerGenBioASA, Bergen (NO)
Filed by BerGenBio ASA, Bergen (NO)
Filed on Jul. 14, 2020, as Appl. No. 16/928,142.
Application 16/928,142 is a division of application No. 16/412,590, filed on May 15, 2019, granted, now 10,766,861.
Application 16/412,590 is a division of application No. 15/533,048, granted, now 10,336,702, issued on Jul. 2, 2019, previously published as PCT/EP2015/081168, filed on Dec. 23, 2015.
Claims priority of application No. 1423087 (GB), filed on Dec. 23, 2014; application No. 1508787 (GB), filed on May 22, 2015; and application No. 1519919 (GB), filed on Nov. 11, 2015.
Prior Publication US 2021/0070708 A1, Mar. 11, 2021
Int. Cl. C07D 213/75 (2006.01); C07D 403/12 (2006.01); C07D 401/12 (2006.01); C07D 237/20 (2006.01); C07D 405/10 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07C 227/12 (2006.01); C07C 227/00 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/50 (2006.01); A61K 31/501 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01)
CPC C07D 213/75 (2013.01) [A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4427 (2013.01); A61K 31/4433 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/50 (2013.01); A61K 31/501 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07C 227/00 (2013.01); C07C 227/12 (2013.01); C07D 237/20 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/10 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)] 2 Claims
 
1. An intermediate compound of formula (II):

OG Complex Work Unit Chemistry
wherein
(a) one of Q1 and Q2 represents a nitrogen atom and the other represents CH, or both Q1 and Q2 represent nitrogen atoms, and Q3 represents CH; or
(b) Q1, Q2 and Q3 all represent nitrogen atoms;
A represents an optionally substituted five- or six-membered aromatic ring;
R3 represents an optionally substituted aryl or heteroaryl ring;
R5 and R6 independently represent H or optionally substituted alkyl; or R5 and R6 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring, optionally containing a heteroatom;
and Rx and Ry independently represent H or a protecting group.