CPC C07D 211/58 (2013.01) [A61P 19/08 (2018.01); A61P 29/00 (2018.01)] | 20 Claims |
1. A compound of formula
or a pharmaceutically acceptable salt thereof,
wherein R1 is —C(═O)R4; R4 is a halo-substituted phenyl, an unsubstituted phenyl, or a C1-C4 alkyl; R2 is a C1-C4 alkoxyl, hydrogen, or a halo; and R3 is hydrogen or a C1-C4 alkyl; or
wherein R1 is an unsubstituted phenyl; R2 is a C1-C4 alkoxyl or hydrogen; and R3 is hydrogen or a C1-C4 alkyl; and
wherein
if R1 is —C(═O)R4 and R4 is a 4-chloro substituted phenyl, R2 and R3 are not both hydrogen;
if R1 is —C(═O)R4 and R4 is the unsubstituted phenyl, (i) R2 and R3 are not both hydrogen or (ii) R2 and R3 are not respectively 4-chloro and hydrogen;
if R1 is —C(═O)R4 and R4 is methyl, R2 and R3 are not respectively 3,4-dichloro and hydrogen, 3,4-dichloro and hydrogen, or 4-bromo and hydrogen;
if R1 is —C(═O)R4 and R4 is ethyl, R2 and R3 are not respectively 3,4-dichloro and hydrogen; and
if R1 is phenyl, R2 and R3 are not respectively hydrogen and methyl.
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