US 11,655,201 B2
Method for preparing 2-tert-butyl-4-methoxyphenol and new crystal form thereof
Xuemin Zhang, Beijing (CN); Xinhua He, Beijing (CN); Tao Zhou, Beijing (CN); Zhenggang Liu, Beijing (CN); Tao Li, Beijing (CN); and Shengming Wu, Beijing (CN)
Assigned to BIOMEDICAL ANALYSIS CENTER, ACADEMY OF MILITARY MEDICAL SCIENCES, Beijing (CN)
Appl. No. 17/271,090
Filed by BIOMEDICAL ANALYSIS CENTER, ACADEMY OF MILITARY MEDICAL SCIENCES, Beijing (CN)
PCT Filed Mar. 23, 2018, PCT No. PCT/CN2018/080103
§ 371(c)(1), (2) Date Feb. 24, 2021,
PCT Pub. No. WO2018/214630, PCT Pub. Date Nov. 29, 2018.
Claims priority of application No. 201710372606.1 (CN), filed on May 24, 2017.
Prior Publication US 2021/0317059 A1, Oct. 14, 2021
Int. Cl. C07C 43/23 (2006.01); C07C 41/40 (2006.01); C07C 41/09 (2006.01)
CPC C07C 43/23 (2013.01) [C07C 41/09 (2013.01); C07C 41/40 (2013.01); C07B 2200/13 (2013.01); C07C 2601/16 (2017.05)] 8 Claims
 
1. A stable crystalline form A of 2-tert-butyl-4-methoxyphenol, wherein: form A has a powder X-ray diffraction pattern expressed in 2θ angles using Cu-Kα radiation having absorption peaks selected from the following positions: 6.27±0.10, 6.94±0.10, 12.27±0.10, 13.36±0.10, 14.01±0.10, 14.79±0.10, 15.31±0.10, 17.05±0.10, 18.30±0.10, 19.00±0.10, 20.47±0.10, 20.98±0.10, 22.37±0.10, 23.68±0.10, 24.55±0.10, 25.37±0.10, 30.83±0.10, 33.12±0.10, 40.50±0.10, and 42.81±0.10.