US 11,654,146 B2
Methods for killing antibiotic tolerant bacteria
Thomas Keith Wood, Port Matilda, PA (US); and Sooyeon Song, Gwangju (KR)
Assigned to THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US)
Filed by THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US)
Filed on Jun. 2, 2021, as Appl. No. 17/337,097.
Claims priority of provisional application 63/033,544, filed on Jun. 2, 2020.
Prior Publication US 2021/0401843 A1, Dec. 30, 2021
Int. Cl. A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61P 31/04 (2006.01); A61K 31/4045 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 31/4045 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01)] 17 Claims
 
1. A method for killing bacterial persister cells and/or dormant “viable but non-culturable” (VBNC) cells in a bacterial population, the method comprising administering to the bacterial population an effective amount of [(5-nitro-3-phenyl-1H-indol-2-yl)methyl]amine having the formula:

OG Complex Work Unit Chemistry
or a salt thereof, [(5-nitro-3-phenyl-1H-indol-2-yl)methyl]amine hydrochloride (NPIMA), having the formula:

OG Complex Work Unit Chemistry
and wherein the bacterial persister cells and/or VBNC comprise bacteria selected from Escherichia spp., Staphylococcus spp., and Pseudomonas spp.