US 11,654,105 B2
Subcutaneous HER2 antibody formulations
Jennifer Eng-Wong, South San Francisco, CA (US); Whitney Kirschbrown, South San Francisco, CA (US); Tarik Ali Khan, Basel (CH); Jasper Lin, South San Francisco, CA (US); Sreedhara Alavattam, South San Francisco, CA (US); Amit Garg, South San Francisco, CA (US); Sarah Heeson, Welwyn Garden City (GB); Tanja Badovinac-Crnjevic, Basel (CH); and Christine Wurth, Basel (CH)
Assigned to Genentech, Inc., South San Francisco, CA (US); and Hoffmann-La Roche, Little Falls, NJ (US)
Filed by Genentech, Inc., South San Francisco, CA (US); and Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed on Aug. 22, 2022, as Appl. No. 17/821,426.
Application 17/821,426 is a division of application No. 16/952,670, filed on Nov. 19, 2020.
Application 16/952,670 is a division of application No. 15/872,648, filed on Jan. 16, 2018, granted, now 10,849,849, issued on Dec. 1, 2020.
Claims priority of provisional application 62/447,359, filed on Jan. 17, 2017.
Prior Publication US 2023/0092354 A1, Mar. 23, 2023
Int. Cl. C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); A61K 39/395 (2006.01); A61K 9/08 (2006.01); A61K 9/00 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 47/20 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); A61K 38/47 (2006.01)
CPC A61K 9/0019 (2013.01) [A61K 9/08 (2013.01); A61K 38/47 (2013.01); A61K 39/001106 (2018.08); A61K 39/39591 (2013.01); A61K 47/183 (2013.01); A61K 47/20 (2013.01); A61K 47/26 (2013.01); A61P 35/00 (2018.01); C07K 16/32 (2013.01); C12Y 302/01035 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/585 (2013.01); C07K 16/28 (2013.01); C07K 16/30 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/90 (2013.01)] 30 Claims
 
1. An article of manufacture containing a single fixed dose of a HER2 antibody comprising the variable light chain and variable heavy chain amino acid sequences of SEQ ID Nos. 7 and 8, respectively, wherein the fixed dose is 600 mg or 1200 mg.