CPC C12Q 1/6837 (2013.01) [C12N 15/1068 (2013.01); C12Q 1/6811 (2013.01)] | 20 Claims |
1. A method of identifying a dimer compound that binds to different molecular targets, the method comprising the steps of:
i) providing a first library of bifunctional complexes, each complex comprising a first display molecule and a first identifier oligonucleotide;
ii) exposing the first library to an environment comprising a first target, and identifying first display molecules that bind to the first target with a predetermined binding affinity;
iii) providing a second library of bifunctional complexes, each complex comprising a second display molecule and a second identifier oligonucleotide;
iv) exposing the second library to an environment comprising a second target, and identifying second display molecules that bind to the second target with a predetermined binding affinity;
v) forming dimer compounds by linking first and second display molecules identified in steps ii) and iv), respectively;
vi) exposing the dimer compounds to an environment comprising the first and second targets; and
vii) identifying dimer compounds binding the first and second targets with a predetermined binding affinity.
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