	US 11,965,160 B2
	Von Willebrand Factor (VWF)-targeting agents and methods of using the same
Shahid M. Nimjee, Columbus, OH (US); Bruce Sullenger, Durham, NC (US); George A. Pitoc, Durham, NC (US); and Juliana Layzer, Durham, NC (US)
Assigned to Duke University, Durham, NC (US); and Ohio State Innovation Foundation, Columbus, OH (US)
Filed by Duke University, Durham, NC (US); and Ohio State Innovation Foundation, Columbus, OH (US)
Filed on Jan. 11, 2021, as Appl. No. 17/146,147.
Application 17/146,147 is a division of application No. 16/334,307, granted, now 10,889,816, previously published as PCT/US2017/052063, filed on Sep. 18, 2017.
Claims priority of provisional application 62/395,642, filed on Sep. 16, 2016.
Prior Publication US 2021/0222170 A1, Jul. 22, 2021
Int. Cl. C07H 21/02 (2006.01); A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 31/7115 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); A61P 7/02 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01)

CPC C12N 15/113 (2013.01) [A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 31/7115 (2013.01); A61K 45/06 (2013.01); A61K 47/554 (2017.08); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61P 7/02 (2018.01); C12N 15/115 (2013.01); C12N 2310/113 (2013.01); C12N 2310/16 (2013.01); C12N 2310/317 (2013.01); C12N 2310/3183 (2013.01); C12N 2310/3515 (2013.01)]

20 Claims

1. An antidote comprising a polynucleotide having at least 90% sequence identity to SEQ ID NO: 157, wherein the antidote is no more than 24 nucleotides in length.