US 11,965,152 B2
Buffer formulation method and system
Thaddaeus Webster, Rollinsford, NH (US); Carrie Mason, Brentwood, NH (US); and Tristan Wilkins, Newmarket, NH (US)
Assigned to Lonza Ltd., Visp (CH)
Filed by Lonza Ltd., Visp (CH)
Filed on Feb. 6, 2020, as Appl. No. 16/783,275.
Claims priority of provisional application 62/803,747, filed on Feb. 11, 2019.
Prior Publication US 2020/0255792 A1, Aug. 13, 2020
Int. Cl. C12M 1/34 (2006.01); B01F 23/45 (2022.01); B01J 19/00 (2006.01); B01F 101/22 (2022.01)
CPC C12M 41/26 (2013.01) [B01F 23/45 (2022.01); B01J 19/0086 (2013.01); C12M 1/3407 (2013.01); C12M 1/3453 (2013.01); C12M 41/12 (2013.01); B01F 2101/22 (2022.01); Y10T 436/108331 (2015.01)] 21 Claims
OG exemplary drawing
 
1. A process for formulating buffer products for feeding to a bioprocess comprising:
combining multiple buffer solutions to form a final buffer product, the multiple buffer solutions including at least a first buffer solution and a second buffer solution;
measuring a conductivity of the final buffer product;
measuring a refractive index of the final buffer product;
comparing the measured conductivity to a preset conductivity range and comparing the measured refractive index to a preset refractive index range; and
selectively adjusting a flow rate of the first buffer solution in relation to a flow rate of the second buffer solution in order to maintain the conductivity and the refractive index of the final buffer product within the preset ranges.