US 11,965,014 B2
Immune synapse-stabilizing chimeric antigen receptor (CAR) T cell
Kyungho Choi, Seoul (KR); Eun-Young Choi, Seoul (KR); Giri Nam, Seoul (KR); Hyung-Bae Park, Seoul (KR); Ji-Eun Lee, Gyeonggi-do (KR); and Hye-Ran Yeon, Gyeonggi-do (KR)
Assigned to TICAROS CO., LTD., Seoul (KR)
Appl. No. 17/638,923
Filed by TICAROS CO., LTD., Seoul (KR)
PCT Filed Jul. 28, 2021, PCT No. PCT/KR2021/009828
§ 371(c)(1), (2) Date Feb. 28, 2022,
PCT Pub. No. WO2022/025638, PCT Pub. Date Feb. 3, 2022.
Claims priority of application No. 10-2020-0094624 (KR), filed on Jul. 29, 2020.
Prior Publication US 2023/0118625 A1, Apr. 20, 2023
Int. Cl. C07K 14/705 (2006.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/70596 (2013.01) [A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 2740/10043 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A chimeric antigen receptor (CAR) comprising:
(a) an antigen-binding domain;
(b) a backbone comprising an extracellular spacer domain and a transmembrane domain; and
(c) an intracellular signaling domain,
wherein the transmembrane domain comprises a CD99 transmembrane domain, and wherein the chimeric antigen receptor comprises a CD99 intracellular juxtamembrane domain.