CPC C07K 14/70596 (2013.01) [A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 2740/10043 (2013.01)] | 19 Claims |
1. A chimeric antigen receptor (CAR) comprising:
(a) an antigen-binding domain;
(b) a backbone comprising an extracellular spacer domain and a transmembrane domain; and
(c) an intracellular signaling domain,
wherein the transmembrane domain comprises a CD99 transmembrane domain, and wherein the chimeric antigen receptor comprises a CD99 intracellular juxtamembrane domain.
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